The Bills don’t defend the pass well but they get turnovers, the Giants weakness. The line reflects the disaster last week by the Giants against Seattle and the Bills beating Philadelphia. Both Seattle and Philly are not good. If Buffalo holds on to the ball and protects Fitzpatrick, two things they have done well this year and the strength of the Giants defense, they should win outright. Pick: Stayaway. I thought Buffalo but it is to early in the year to expect turnover and assume they will continue to happen on either end
| New York Giants | Buffalo Bills | |
| On Offense | On Defense | |
| Yards per Pass Attempt | 8.396 (3) | 7.458 (21) |
| Turnovers per Play | 0.029 (22) | 0.05 (2) |
| Sacks Allowed per Play | 0.045 (25) | 0.016 (31) |
| % Running Attempts | 42.6% (12) | 39.1% (13) |
| On Defense | On Offense | |
| Yards per Pass Attempt | 6.789 (14) | 6.971 (15) |
| Turnovers per Play | 0.032 (7) | 0.016 (5) |
| Sacks per Play | 0.052 (4) | 0.013 (1) |
| % Running Attempts | 41.8% (18) | 44% (8) |
| Projecting Winning % | 0.658 | 0.673 |
| Opponents Projected Win% | 0.350 | 0.505 |
| Actual Winning % | 0.600 | 0.800 |
| Winning Factor | 0.603 | 0.643 |