Best game of the weekend. Two teams playing well and both great at holding on to the ball and taking it away from their opponent, with the 49ers great at dictating tempo on both sides of the ball. Predicting turnovers is harder than picking games. Priced about right with two “surprise” teams. Both performing well against below average opposition. Pick: Stayaway
| Detroit Lions | San Francisco 49ers | |
| On Offense | On Defense | |
| Yards per Pass Attempt | 7.548 (11) | 6.85 (17) |
| Turnovers per Play | 0.013 (1) | 0.045 (3) |
| Sacks Allowed per Play | 0.019 (3) | 0.038 (14) |
| % Running Attempts | 38.4% (22) | 34.3% (6) |
| On Defense | On Offense | |
| Yards per Pass Attempt | 5.905 (4) | 7.093 (13) |
| Turnovers per Play | 0.034 (5) | 0.014 (3) |
| Sacks per Play | 0.037 (15) | 0.048 (27) |
| % Running Attempts | 37.3% (11) | 50.5% (2) |
| Projecting Winning % | 0.821 | 0.762 |
| Opponents Projected Win% | 0.468 | 0.434 |
| Actual Winning % | 1.000 | 0.800 |
| Winning Factor | 0.758 | 0.704 |